- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Polygalacin D
- Price: ￥3928.0/20mg ￥1288.0/5mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Polygalacin D
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
66663-91-0
66663-91-0 structure
- Name: Polygalacin D
- Chemical Name: polygalacin D
- CAS Number: 66663-91-0
- Molecular Formula: C57H92O27
- Molecular Weight: 1209.324
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-09-18 20:24:46
- Modify Date: 2024-01-01 18:36:45
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Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1]
| Name | polygalacin D |
|---|---|
| Synonyms |
α-L-Arabinopyranose, O-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-xylopyranosyl-(1->4)-O-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β,16α)-3-(β- 
D-glucopyranosyloxy)-2,16,23-trihydroxy-28-oxoolean-12-en-28-yl]-
polygalacin-D POLYGALACIN D 3-O-[(2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β,16α)-3-(β-D-glucopyranosyloxy)-2,16,23-t ; rihydroxy-28-oxoolean-12-en-28-yl]-α-L-arabinopyranose |
| Description | Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum (Jacq.) with anticancer and anti-proliferative properties.PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis[1] |
|---|---|
| Related Catalog | |
| Target |
IC50: IAP[1] |
| In Vitro | Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1]. Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1]. Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM, 40µM Incubation Time: 48 hours Result: Inhibited the proliferation of NSCLC cell lines. Apoptosis Analysis[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Induced apoptosis of NSCLC cell lines. Western Blot Analysis[1] Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C57H92O27 |
| Molecular Weight | 1209.324 |
| Exact Mass | 1208.582642 |
| PSA | 433.05000 |
| LogP | 0.50 |
| Index of Refraction | 1.652 |
| Storage condition | 2-8℃ |