102978-40-5
102978-40-5 structure
- Name: (±)- 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy
- Chemical Name: 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4 H)-trione
- CAS Number: 102978-40-5
- Molecular Formula: C13H13NO5
- Molecular Weight: 263.25
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
- Create Date: 2018-06-13 13:45:21
- Modify Date: 2025-08-25 18:02:09
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(rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2].
| Name | 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4 H)-trione |
|---|---|
| Synonyms |
4-ethyl-6-oxo-1,4,7,8-tetrahydro-4-hydroxy-pyrano [3,4-f]indolizine-3,10(6H)-dione
4-ethyl-6-methyl-DBT 4-ethyl-1,4,7,8-tetrahydro-4-hydroxypyrano[3,4-f]indolizine-3,6,10-trione 4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione 7,8-dihydro-4-ethyl-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione |
| Description | (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C13H13NO5 |
|---|---|
| Molecular Weight | 263.25 |
| Exact Mass | 263.07900 |
| PSA | 85.60000 |
| LogP | 0.08910 |
| Precursor 9 | |
|---|---|
| DownStream 10 | |
![ethyl 2-acetoxy-2-[6-(acetoxymethyl)-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-7-yl]butanoate structure](https://image.chemsrc.com/caspic/176/128434-27-5.png)
![Ethyl 2-(6'-cyano-5'-oxo-3',5'-dihydro-2'H-spiro[[1,3]dioxolane-2,1'-indolizin]-7'-yl)acetate structure](https://image.chemsrc.com/caspic/277/58610-65-4.png)
![ethyl bromo-[6-cyano-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-7-yl] acetate structure](https://image.chemsrc.com/caspic/084/110714-43-7.png)
![ethyl acetoxy-[6-cyano-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-7-yl]acetate structure](https://image.chemsrc.com/caspic/328/128434-23-1.png)
![ethyl 2-acetoxy-2-[6-cyano-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-7-yl]butanoate structure](https://image.chemsrc.com/caspic/290/128434-24-2.png)
![6-(acetoxymethyl)-1,1'-(ethylenedioxy)-7-[1'-(ethoxycarbonyl)propyl]-5-oxo-Δ6(8)-tetrahydroindolizine structure](https://image.chemsrc.com/caspic/350/73427-97-1.png)
![4-ethyl-4,6,7,8-tetrahydro-1H-pyrano[3,4-f]indolizine-3,10-dione structure](https://image.chemsrc.com/caspic/460/43083-10-9.png)
![1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4-hydroxy- structure](https://image.chemsrc.com/caspic/436/31456-25-4.png)
