CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UI3850000
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CHEMICAL NAME :
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Propylamine, N-methyl-N-nitroso-
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CAS REGISTRY NUMBER :
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924-46-9
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BEILSTEIN REFERENCE NO. :
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1745070
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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17
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MOLECULAR FORMULA :
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C4-H10-N2-O
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MOLECULAR WEIGHT :
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102.16
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WISWESSER LINE NOTATION :
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ONN3&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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106 mg/kg
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach Liver - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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77 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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493 mg/kg
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TOXIC EFFECTS :
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Liver - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Blood - hemorrhage
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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160 mg/kg/23W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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240 mg/kg/45W-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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185 mg/kg/48W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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490 mg/kg/23W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Sense Organs and Special Senses (Olfaction) - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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1250 mg/kg/24W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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100 mg/kg female 14 day(s) after conception
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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225 mg/kg/18W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
MUTATION DATA
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TYPE OF TEST :
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Mutation in mammalian somatic cells
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TEST SYSTEM :
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Rodent - hamster Lung
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DOSE/DURATION :
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700 umol/L
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REFERENCE :
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50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology, Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983
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