191219-80-4

191219-80-4 structure

Name: YM 976
Chemical Name: 4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2-one
CAS Number: 191219-80-4
Molecular Formula: C₁₇H₁₆ClN₃O
Molecular Weight: 313.78100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-12-23 21:10:57
Modify Date: 2024-01-09 17:02:59
YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1].

Name	4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2-one
Synonyms	YM 976 Tocris-1821 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one

Description	YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Hiroshi Moriuchi, et al. Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur J Pharmacol. 2003 May 30;470(1-2):57-64.

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