51555-87-4
51555-87-4 structure
- Name: Thiodigalactoside
- Chemical Name: thiodigalactoside
- CAS Number: 51555-87-4
- Molecular Formula: C12H22O10S
- Molecular Weight: 358.36200
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2016-02-05 06:06:13
- Modify Date: 2025-08-26 20:40:03
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Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].
| Name | thiodigalactoside |
|---|---|
| Synonyms | D-Galactopyranosyl-b-D-thiogalactopyranoside |
| Description | Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2]. |
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| Related Catalog | |
| Target |
Kd: 24 μM (GAL1) and 49 μM (GAL3)[1] |
| In Vitro | Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining[1]. |
| In Vivo | Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain[2]. Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.[2]. Animal Model: Five-week-old Sprague-Dawley (SD) male rats[2] Dosage: 5 mg/kg Administration: IP; once per week for 5 weeks Result: Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure. |
| References |
| Molecular Formula | C12H22O10S |
|---|---|
| Molecular Weight | 358.36200 |
| Exact Mass | 358.09300 |
| PSA | 205.60000 |
| WGK Germany | 3 |
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~%
51555-87-4 |
| Literature: Bogusiak, Jadwiga; Szeja, Wieslaw Carbohydrate Research, 1985 , vol. 141, p. 165 - 167 |
| Precursor 2 | |
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| DownStream 0 | |