25001-57-4
25001-57-4 structure
- Name: justicidin A
- Chemical Name: 9-(1,3-benzodioxol-5-yl)-4,6,7-trimethoxy-3H-benzo[f][2]benzofuran-1-one
- CAS Number: 25001-57-4
- Molecular Formula: C22H18O7
- Molecular Weight: 394.37400
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-04-20 08:49:29
- Modify Date: 2025-08-24 22:54:08
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justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer[1].
| Name | 9-(1,3-benzodioxol-5-yl)-4,6,7-trimethoxy-3H-benzo[f][2]benzofuran-1-one |
|---|---|
| Synonyms |
Justicidins
4,6,7-trimethoxy-9-(1,3-benzodioxol-5-yl)naphtho[2,3-c]furan-1(3H)-one 9-benzo[1,3]dioxol-5-yl-4,6,7-trimethoxy-3H-naphtho[2,3-c]furan-1-one O-methyldiphyllin Justicidin A diphyllin methyl ether 9-(1,3-Benzodioxol-5-yl)-4,6,7-trimethoxynaphtho[2,3-c]furan-1(3H)-one UNII-Q58EXN1G4M |
| Description | justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer[1]. |
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| Related Catalog | |
| In Vitro | justicidin A (0-2.5 μM; 6 天) 抑制结直肠癌细胞的生长，对 HT-29、HCT 116、SiHa、MCF7 和 T24 细胞的 IC50 值分别为 0.110、0.400、0.020、1.540 和 0.004 μM[1]。 justicidin A (0.75 和 5 μM; 0-72 h) 诱导结直肠癌细胞凋亡[1]。 justicidin A (0.75 和 5 μM; 0-72 h) 诱导人结直肠癌细胞中 caspases 及其靶蛋白的裂解[1]。 justicidin A (0.75 和 5 μM; 0-72 h) 损伤线粒体，并从线粒体释放 cyto c 和 Smac[1]。 justicidin A (0.75 和 5 μM; 0-72 h) 降低 Ku70 水平，导致 Bax 从细胞质转位到线粒体[1]。 Cell Viability Assay[1] Cell Line: HT-29, HCT 116, SiHa, MCF7 and T24 cells Concentration: 0-2.5 μM Incubation Time: 6 days Result: Inhibited cell growth in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: HT-29 and HCT 116 cells Concentration: 0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells) Incubation Time: 0, 12, 16, 20, 24, 48, and 72 hours Result: Induced apoptosis in a time-dependent manner. Increased the population of sub-G 1 cells in a time-dependent manner. Western Blot Analysis[1] Cell Line: HT-29 and HCT 116 cells Concentration: 0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells) Incubation Time: 0, 12, 16, 20, 24, 48, 72, and 96 hours Result: Decreased the amount of cytosolic Ku70 in HCT 116 cells and decreased (0.6-fold) at 48 h and reached the lowest level (0.33-fold) at 96 h. Western Blot Analysis[1] Cell Line: HT-29 and HCT 116 cells Concentration: 0.75 μM (HT-29 cells) and 5 μM (HCT 116 cells) Incubation Time: 0, 12, 16, 20, 24, 48, and 72 hours Result: Induced the cleavage of caspases and their target proteins. |
| In Vivo | justicidin A (6.2 mg/kg; p.o.; 每天, 持续 56 天) 抑制小鼠中人类结直肠癌细胞的生长[1]。 Animal Model: NOD-SCID mice with HT-29 cells xenograftes[1] Dosage: 6.2 mg/kg Administration: Oral administration; daily, for 56 days Result: Inhibited tumor growth and decreased tumor weight. |
| Density | 1.366g/cm3 |
|---|---|
| Boiling Point | 644.5ºC at 760mmHg |
| Molecular Formula | C22H18O7 |
| Molecular Weight | 394.37400 |
| Flash Point | 282.4ºC |
| Exact Mass | 394.10500 |
| PSA | 72.45000 |
| LogP | 3.93170 |
| Vapour Pressure | 1.69E-16mmHg at 25°C |
| Index of Refraction | 1.641 |
| HS Code | 2932999099 |
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~96%
25001-57-4 |
| Literature: Charlton, James L.; Oleschuk, Curtis J.; Chee, Gaik-Lean Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3452 - 3457 |
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25001-57-4 |
| Literature: Plaumann, Heinz P.; Smith, James G.; Rodrigo, Russell Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 354 - 355 |
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25001-57-4 |
| Literature: Charlton, James L.; Oleschuk, Curtis J.; Chee, Gaik-Lean Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3452 - 3457 |
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25001-57-4 |
| Literature: Charlton, James L.; Oleschuk, Curtis J.; Chee, Gaik-Lean Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3452 - 3457 |
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25001-57-4 |
| Literature: Plaumann, Heinz P.; Smith, James G.; Rodrigo, Russell Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 354 - 355 |
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25001-57-4 |
| Literature: Plaumann, Heinz P.; Smith, James G.; Rodrigo, Russell Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 354 - 355 |
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25001-57-4 |
| Literature: Abdullaev, N. D.; Yagudaev, M. R.; Batirov, E. Kh.; Malikov, V. M. Chemistry of Natural Compounds, 1987 , vol. 23, p. 63 - 74 Khimiya Prirodnykh Soedinenii, 1987 , # 1 p. 76 - 90 |
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25001-57-4 |
| Literature: Wang; Ripka Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2555 - 2557 |
| Precursor 8 | |
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| DownStream 0 | |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |