Top Suppliers:I want be here
Related CAS#:
31098-42-7 14653-77-1
17002-55-0 20537-88-6
10027-65-3 112901-68-5
59178-37-9 1345018-75-8
1189056-65-2 24628-34-0

31098-42-7

31098-42-7 structure
31098-42-7 structure
  • Name: Amifostine thiol
  • Chemical Name: wr-1065
  • CAS Number: 31098-42-7
  • Molecular Formula: C5H14N2S
  • Molecular Weight: 134.24300
  • Catalog: Signaling Pathways Apoptosis MDM-2/p53
  • Create Date: 2018-12-27 23:09:01
  • Modify Date: 2024-01-08 16:21:51
  • Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].
Name wr-1065
Synonyms N-2-mercaptoethyl-1,3-diaminopropane
WR1065
Amifostine Thiol Dihydrochloride
2-(3-aminopropylamino)ethanethiol
Description Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].
Related Catalog
Target

p53[2]
In Vitro Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures[1]. Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability[1]. Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment[1]. Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage[1]. Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81[2]. Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells[3].
References

[1]. Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45(12): 1674–1681.

[2]. Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87. J Biol Chem. 2003 Apr 4;278(14):11879-87.

[3]. J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30(6): 283–294.
Molecular Formula C5H14N2S
Molecular Weight 134.24300
Exact Mass 134.08800
PSA 76.85000
LogP 0.94580
HS Code 2930909090
Precursor  2

DownStream  0

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Chemsrc provides CAS#:31098-42-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 31098-42-7 | Chemsrc address: https://www.chemsrc.com/en/baike/631696.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved