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4375-07-9

4375-07-9 structure
4375-07-9 structure
  • Name: Epipodophyllotoxin
  • Chemical Name: (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
  • CAS Number: 4375-07-9
  • Molecular Formula: C22H22O8
  • Molecular Weight: 414.40500
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2016-11-11 23:53:59
  • Modify Date: 2025-08-25 13:26:45
  • (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
Name (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tet rahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
Synonyms Sunphenon EGC
Epipodophyllotoxin
EPIGALLOCATECHIN
Teacatechin II
epi
Galloepicatechin
epigallocatechol
Greenteacatechins
Description (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
Related Catalog
References

[1]. Magedov IV, et, al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012 Oct 28; 48(84): 10416-8.
Density 1.37g/cm3
Boiling Point 597.9ºC at 760 mmHg
Melting Point 160.3 °C
Molecular Formula C22H22O8
Molecular Weight 414.40500
Flash Point 210.2ºC
Exact Mass 414.13100
PSA 92.68000
LogP 2.40920
Index of Refraction 1.605

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV2520000
CAS REGISTRY NUMBER :
4375-07-9
BEILSTEIN REFERENCE NO. :
0099162
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H22-O8
MOLECULAR WEIGHT :
414.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
135 mg/kg
SEX/DURATION :
female 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
20 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,512,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5374 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 214 (estimated) No. of Female Employees: 214 (estimated)
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