Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (R)-(-)-Ibuprofen
Price: ￥2286.0/1g ￥916.0/250mg ￥506.0/100mg
Purity: 96.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (R)-(-)-Ibuprofen
Price: $Inquiry/25mg $Inquiry/50mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-(-)-CROTONYLCYCLOPENTANEDIENYLIRONCARBONYLTRIPHENYLPHOSPHINECOMPLEX
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: (R)-(-)-Ibuprofen
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (R)-(-)-IBUPROFEN
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

51146-57-7

51146-57-7 structure

51146-57-7 structure

Name: (R)-(-)-Ibuprofen
Chemical Name: levibuprofen
CAS Number: 51146-57-7
Molecular Formula: C₁₃H₁₈O₂
Molecular Weight: 206.281
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-05-30 08:00:00
Modify Date: 2024-01-02 19:11:30
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

Name	levibuprofen
Synonyms	Inoven Lebrufen (RS)-ibuprofen Ibumetin Femadon 2-(4-Isobutylphenyl)propionic acid QVY1&R D1Y1&1 l-Ibuprofen Para-Isobutylhydratropic Acid Ibuprofen (2R)-2-(4-Isobutylphenyl)propanoic acid (R)-2-(4-Isobutylphenyl)propanoic acid Benzeneacetic acid, α-methyl-4-(2-methylpropyl)- (±)-ibuprofen Novogent N Ibutid fenbid 2-(4-Isobutylphenyl)propanoic acid MOTRIN Dolgirid (R)-Ibuprofen Amibufen (-)-ibuprofen Nurofen (R)-(-)-Ibuprofen Racemic ibuprofen (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid Advil Brufen Dolo-Dolgit Seclodin UNII:WK2XYI10QM Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)- IbU Panafen

Description	(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	NF-κB
In Vitro	(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2].
References	[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.

Density	1.0±0.1 g/cm3
Boiling Point	319.6±11.0 °C at 760 mmHg
Melting Point	41-42ºC
Molecular Formula	C₁₃H₁₈O₂
Molecular Weight	206.281
Flash Point	216.7±14.4 °C
Exact Mass	206.130676
PSA	37.30000
LogP	3.72
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.519

HS Code	2916399090

Precursor 9
6448-14-2 15687-27-1 62784-66-1 110282-71-8
1187670-13-8 51407-46-6 61566-34-5 298197-67-8
2039-82-9
DownStream 1
34352-86-8

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%