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51146-57-7

51146-57-7 structure
51146-57-7 structure
  • Name: (R)-(-)-Ibuprofen
  • Chemical Name: levibuprofen
  • CAS Number: 51146-57-7
  • Molecular Formula: C13H18O2
  • Molecular Weight: 206.281
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2018-05-30 08:00:00
  • Modify Date: 2025-08-20 09:37:24
  • (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Name levibuprofen
Synonyms Inoven
Lebrufen
(RS)-ibuprofen
Ibumetin
Femadon
2-(4-Isobutylphenyl)propionic acid
QVY1&R D1Y1&1
l-Ibuprofen
Para-Isobutylhydratropic Acid
Ibuprofen
(2R)-2-(4-Isobutylphenyl)propanoic acid
(R)-2-(4-Isobutylphenyl)propanoic acid
Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-
(±)-ibuprofen
Novogent N
Ibutid
fenbid
2-(4-Isobutylphenyl)propanoic acid
MOTRIN
Dolgirid
(R)-Ibuprofen
Amibufen
(-)-ibuprofen
Nurofen
(R)-(-)-Ibuprofen
Racemic ibuprofen
(2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Advil
Brufen
Dolo-Dolgit
Seclodin
UNII:WK2XYI10QM
Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)-
IbU
Panafen
Description (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
Related Catalog
Target

NF-κB

In Vitro (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2].
References

[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14.

[2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52.
Density 1.0±0.1 g/cm3
Boiling Point 319.6±11.0 °C at 760 mmHg
Melting Point 41-42ºC
Molecular Formula C13H18O2
Molecular Weight 206.281
Flash Point 216.7±14.4 °C
Exact Mass 206.130676
PSA 37.30000
LogP 3.72
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.519
HS Code 2916399090
HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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