Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzoic acid,4-amino-2-hydroxy-, 2-(diethylamino)ethyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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487-53-6

487-53-6 structure

Name: Hydroxyprocaine
Chemical Name: 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate
CAS Number: 487-53-6
Molecular Formula: C₁₃H₂₀N₂O₃
Molecular Weight: 252.30900
Create Date: 2018-09-02 18:25:28
Modify Date: 2025-08-25 18:37:02

Name	2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate
Synonyms	4-Amino-2-hydroxy-benzoesaeure-(2-diaethylamino-aethylester) Metahydroxyprocaine Oxyprocain Hydroxyprocaine Oxycaine Hydroxynovocain 2-Diethylaminoethyl p-aminosalicylate 4-Amino-salicylsaeure-(2-diethylamino-ethylester) Oxyprocaine m-Hydroxyprocaine Oxiprocainum 4-Amino-2-hydroxy-benzoesaeure-(2-diethylamino-ethylester) p-Amino-salicylsaeure-diaethylaminoaethyl-ester Hydroxy-procain 4-amino-2-hydroxy-benzoic acid-(2-diethylamino-ethyl ester) Diethylaminoethyl p-aminosalicylate MFCD00047845

Density	1.158g/cm3
Boiling Point	408.7ºC at 760mmHg
Molecular Formula	C₁₃H₂₀N₂O₃
Molecular Weight	252.30900
Flash Point	201ºC
Exact Mass	252.14700
PSA	75.79000
LogP	2.05420
Vapour Pressure	2.9E-07mmHg at 25°C
Index of Refraction	1.565

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VO1575000

CHEMICAL NAME :: Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 487-53-6

BEILSTEIN REFERENCE NO. :: 2650192

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H20-N2-O3

MOLECULAR WEIGHT :: 252.35

WISWESSER LINE NOTATION :: ZR CQ DVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 2,112,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 10,284,1951

HS Code	2922509090

65-49-6

487-53-6

Literature: Tanaka; Asami Journal of the Scientific Research Institute, Tokyo, 1954 , vol. 48, p. 287,293

16987-14-7

109-89-7

487-53-6

Literature: Tanaka; Asami Journal of the Scientific Research Institute, Tokyo, 1954 , vol. 48, p. 287,293 Full Text Show Details Rheinpreussen A.G. Patent: DE954425 , 1956 ; Full Text Show Details Steinkohlen-Bergwerk Rheinpreussen Patent: DE842944 , 1951 ; DRP/DRBP Org.Chem.

65-49-6

100-35-6

487-53-6

Literature: Chabrier et al. Bulletin de la Societe Chimique de France, 1956 , p. 1669 Full Text Show Details Giudicelli et al. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1956 , vol. 243, p. 108

65-49-6

100-37-8

487-53-6

Literature: Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742 Full Text Show Details Steinkohlen-Bergwerk Rheinpreussen Patent: DE842944 , 1951 ; DRP/DRBP Org.Chem.

117869-04-2

100-37-8

487-53-6

Literature: Rheinpreussen A.G. Patent: US2763678 , 1953 ; Full Text Show Details Rheinpreussen A.G. Patent: DE954425 , 1956 ;

408536-66-3

109-89-7

487-53-6

Literature: Kakemi; Arita; Kitazawa; Sagawa Chemical and pharmaceutical bulletin, 1967 , vol. 15, # 12 p. 1828 - 1840

Precursor 7
65-49-6 16987-14-7 109-89-7 100-35-6
100-37-8 117869-04-2 408536-66-3
DownStream 1
150-77-6

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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