163271-32-7

163271-32-7 structure

Name: 5-ALA benzyl ester hydrochloride
Chemical Name: benzyl 5-amino-4-oxopentanoate,hydrochloride
CAS Number: 163271-32-7
Molecular Formula: C₁₂H₁₆ClNO₃
Molecular Weight: 257.713
Catalog: Research Areas Cancer
Create Date: 2018-06-14 10:18:10
Modify Date: 2024-01-12 18:11:02
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].

Name	benzyl 5-amino-4-oxopentanoate,hydrochloride
Synonyms	5-Aminolevulinic acid benzyl ester hydrochloride Benzyl 5-amino-4-oxopentanoate hydrochloride (1:1) A-6130 Pentanoic acid, 5-amino-4-oxo-, phenylmethyl ester, hydrochloride (1:1) 5-Amino-4-oxopentanoic acid benzyl ester hydrochloride

Description	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].
Related Catalog	Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].
In Vivo	Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3]. Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3] Dosage: 31 mg/kg Administration: i.v. ; 1 hours Result: Reducing the dose of 5-ALA benzyl ester hydrochloride resulted in a dose-dependent reduction in the concentration of porphyrins accumulating in the CaNT tumour.
References	[1]. Hirschberg H, et al. ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. J Neurooncol. 2002 Mar;57(1):1-7. [2]. Brunner H, et al. The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 Nov;74(5):721-5. [3]. Tunstall RG, et al. Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo. Br J Cancer. 2002 Jul 15;87(2):246-50.

HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%