958295-17-5

958295-17-5 structure

Name: AGN 196996
Chemical Name: Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]
CAS Number: 958295-17-5
Molecular Formula: C₂₄H₂₀BrNO₅
Molecular Weight: 482.32300
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2018-02-12 08:00:00
Modify Date: 2024-01-05 17:07:19
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Name	Benzoic acid, 4-[[3-bromo-4-ethoxy-5-(4-methylbenzoyl)benzoyl]amino]
Synonyms	AGN 196996

Description	AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR Research Areas >> Cancer
References	[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.