778596-26-2

778596-26-2 structure

Name: HO-PEG10-CH2CH2COO<sup>t</sup>Bu
Chemical Name: tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
CAS Number: 778596-26-2
Molecular Formula: C₂₇H₅₄O₁₃
Molecular Weight: 586.71000
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-11-20 00:57:10
Modify Date: 2024-01-10 16:33:29
Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].

Name	tert-butyl 1-hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
Synonyms	HO-PEG10-CH2CH2COOtBu

Description	Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent [2]. Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5.