98326-32-0
98326-32-0 structure
- Name: Senazodan
- Chemical Name: 3-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydro-1H-pyridazin-6-one
- CAS Number: 98326-32-0
- Molecular Formula: C15H14N4O
- Molecular Weight: 266.29800
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2016-01-12 22:17:51
- Modify Date: 2024-02-04 15:42:21
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Senazodan is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.
| Name | 3-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydro-1H-pyridazin-6-one |
|---|---|
| Synonyms |
Senazodan
6-[4-(pyridin-4-ylamino)phenyl]-4,5-dihydropyridazin-3(2h)-one 3(2H)-Pyridazinone,4,5-dihydro-6-(4-(4-pyridinylamino)phenyl) 6-(4-(4-Pyridinylamino)phenyl)-4,5-dihydro-3(2H)-pyridazinone UNII-427L2I2KIM |
| Description | Senazodan is a Ca2+ sensitiser, and also shows inhibition effect on PDE III. |
|---|---|
| Related Catalog | |
| In Vitro | Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity[1]. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhance Ca2+ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III[2]. |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Molecular Formula | C15H14N4O |
| Molecular Weight | 266.29800 |
| Exact Mass | 266.11700 |
| PSA | 73.10000 |
| LogP | 1.57270 |
| Index of Refraction | 1.677 |