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189275-71-6

189275-71-6 structure

189275-71-6 structure

Name: Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
Chemical Name: ac-wehd-cho
CAS Number: 189275-71-6
Molecular Formula: C₂₈H₃₃N₇O₉
Molecular Weight: 611.60
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2018-10-22 13:00:39
Modify Date: 2025-08-20 16:01:16
Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

Name	ac-wehd-cho
Synonyms	N-ACETYL-TRP-GLU-HIS-ASPARTINAL N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-histidinamide AC-WEHD-ALDEHYDE PASE-INHIBITOR VIII Acetyl-tryptyl-glutamyl-histidyl-aspartal AC-TRP-GLU-HIS-ASP-ALDEHYDE PASE-1 INHIBITOR VIII AC-TRP-GLU-HIS-ASP-CHO N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-histidinamide L-Histidinamide, N-acetyl-L-tryptophyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

Description	Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Research Areas >> Inflammation/Immunology
Target	Caspase-1:56 pM (Ki)
References	[1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. [2]. Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55.

Density	1.4±0.1 g/cm3
Boiling Point	1250.2±65.0 °C at 760 mmHg
Molecular Formula	C₂₈H₃₃N₇O₉
Molecular Weight	611.60
Flash Point	709.9±34.3 °C
Exact Mass	611.233948
PSA	252.54000
LogP	-0.50
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.633

WGK Germany	3

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