478698-32-7

478698-32-7 structure

Name: 4,4-Difluoro-3,3-dimethyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}- L-proline
Chemical Name: 4,4-Difluoro-3,3-dimethyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}- L-proline
CAS Number: 478698-32-7
Molecular Formula: C₁₂H₁₉F₂NO₄
Molecular Weight: 279.28000
Create Date: 2017-06-21 11:58:01
Modify Date: 2024-01-20 17:38:55

Name	4,4-Difluoro-3,3-dimethyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}- L-proline
Synonyms	(2S)-4,4-difluoro-3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 1-hydroxymethyl-4-(4-(1,1-dimethylethoxycarbonyl)piperazinyl)benzene 1-(tert-Butoxycarbonyl)-4-(4-hydroxymethylphenyl)piperazine 4,4-difluoro-3,3-dimethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE (2S)-4,4-difluoro-3,3-dimethyl-N-Boc-proline 4-[4-(methoxycarbonyl)phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester 1-(tert-butoxycarbonyl)-4-(4-methoxycarbonylphenyl)piperazine 4-(4-N-Boc-piperazinyl)benzyl alcohol 4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester Methyl 4-(N-Boc-N'-piperazinyl)benzoate 1-(tert-butoxycarbonyl)-4,4-difluoro-3,3-dimethylpyrrolidine-2-carboxylic acid tert-butyl 4-(4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate tert-butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate

Density	1.24g/cm3
Boiling Point	348.6ºC at 760 mmHg
Molecular Formula	C₁₂H₁₉F₂NO₄
Molecular Weight	279.28000
Exact Mass	279.12800
PSA	66.84000
LogP	2.28970
Index of Refraction	1.474

854375-33-0

~68%

478698-32-7

854375-31-8

Literature: Hu, Shanghui; Martinez, Carlos A.; Kline, Billie; Yazbeck, Daniel; Tao, Junhua; Kucera, David J. Organic Process Research and Development, 2006 , vol. 10, # 3 p. 650 - 654

478698-31-6

~95%

478698-32-7

Literature: Agouron Pharmaceuticals, Inc. Patent: US2004/204591 A1, 2004 ;

478698-30-5

478698-32-7

Literature: Rossi, Francesco; Corcella, Francesco; Caldarelli, Francesco Saverio; Heidempergher, Franco; Marchionni, Chiara; Auguadro, Miriam; Cattaneo, Marco; Ceriani, Lucio; Visentin, Giuseppina; Ventrella, Giambattista; Pinciroli, Vittorio; Ramella, Giuliano; Candiani, Ilaria; Bedeschi, Angelo; Tomasi, Attilio; Kline, Billie J.; Martinez, Carlos A.; Yazbeck, Daniel; Kucera, David J. Organic Process Research and Development, 2008 , vol. 12, # 2 p. 322 - 338

848444-88-2

478698-32-7

854375-31-8

Literature: Hu, Shanghui; Martinez, Carlos A.; Kline, Billie; Yazbeck, Daniel; Tao, Junhua; Kucera, David J. Organic Process Research and Development, 2006 , vol. 10, # 3 p. 650 - 654

Precursor 2
854375-33-0 848444-88-2
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4