482-70-2

482-70-2 structure

Name: Chimaphilin
Chemical Name: 2,7-dimethylnaphthalene-1,4-dione
CAS Number: 482-70-2
Molecular Formula: C₁₂H₁₀O₂
Molecular Weight: 186.21
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK IGF-1R
Create Date: 2018-05-07 08:00:00
Modify Date: 2024-01-15 18:45:19
Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].

Name	2,7-dimethylnaphthalene-1,4-dione
Synonyms	1,2,7-dimethyl 2,7-dimethylnaphthoquinone 2,7-Dimethyl-1,4-naphthoquinone Chimaphylin 2,7-dimethylnaphtho-1,4-quinone Chimaphilin 1.4-Dioxo-2.7-dimethyl-1.4-dihydro-naphthalin

Description	Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R
Target	0.086 μM (IGF-1R)[1]
References	[1]. Daqian W, et al. Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like growth factor-I receptor (IGF-IR) signaling. Chem Biol Interact. 2015 Jul 25;237:25-30. [2]. Ma WD, et al. Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway. Food Chem Toxicol. 2014 Aug;70:1-8.

Density	1.187g/cm3
Boiling Point	346.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₀O₂
Molecular Weight	186.21
Flash Point	130.1ºC
Exact Mass	186.06800
PSA	34.14000
LogP	2.32030
Vapour Pressure	5.6E-05mmHg at 25°C
Index of Refraction	1.583

582-16-1

~90%

482-70-2

Literature: Skarzewski, Jacek Tetrahedron, 1984 , vol. 40, # 23 p. 4997 - 5000

52062-24-5

482-70-2

Literature: Boisvert, Louise; Brassard, Paul Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 4052 - 4059

19832-87-2

482-70-2

Literature: Boisvert, Louise; Brassard, Paul Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 4052 - 4059

412321-01-8

482-70-2

Literature: Inouye,H.; Arai,T. Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 533 - 539

553-97-9

482-70-2

Literature: Inouye,H.; Arai,T. Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 533 - 539

78-79-5

482-70-2

Literature: Inouye,H.; Arai,T. Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 533 - 539

52062-24-5

19832-87-2

482-70-2

Literature: Boisvert, Louise; Brassard, Paul Tetrahedron Letters, 1983 , vol. 24, # 24 p. 2453 - 2456

33121-78-7

482-70-2

Literature: Ges. f. Teerverwertung Patent: DE301079 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 209

582-16-1

64-19-7

482-70-2

Literature: Ges. f. Teerverwertung Patent: DE301079 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 13, p. 209 Full Text Show Details Weiszgerber; Kruber Chemische Berichte, 1919 , vol. 52, p. 363

Precursor 8
582-16-1 52062-24-5 19832-87-2 412321-01-8
553-97-9 78-79-5 33121-78-7 64-19-7
DownStream 1
528-44-9

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