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461-78-9

461-78-9 structure
461-78-9 structure
Name 1-(4-chlorophenyl)-2-methylpropan-2-amine
Synonyms Lucofen SA
Chlorphenterminum [INN-Latin]
Effox
Chlorphenterminum
Clorfentermina [INN-Spanish]
3-(4-chlorophenyl)-2-methyl-2-propylamin
Clorfentermina
Teramine
chlorophentermine
chlorphentermine
Desopimon
1,1-dimethyl-2-(4-chlorophenyl)ethylamine
Density 1.074g/cm3
Boiling Point 255.8ºC at 760mmHg
Molecular Formula C10H14ClN
Molecular Weight 183.67800
Flash Point 127ºC
Exact Mass 183.08100
PSA 26.02000
LogP 3.32010
Vapour Pressure 0.016mmHg at 25°C
Index of Refraction 1.537

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SH1050000
CHEMICAL NAME :
Phenethylamine, p-chloro-alpha,alpha-dimethyl-
CAS REGISTRY NUMBER :
461-78-9
BEILSTEIN REFERENCE NO. :
1099928
LAST UPDATED :
199709
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C10-H14-Cl-N
MOLECULAR WEIGHT :
183.70
WISWESSER LINE NOTATION :
ZX1&1&1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
5357 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic Vascular - BP elevation not characterized in autonomic section
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
720 mg/kg/6W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg/15W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg/6W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3900 mg/kg/13W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
480 mg/kg
SEX/DURATION :
female 10-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
300 mg/kg/5D (Continuous)
REFERENCE :
40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year: -,459,1978 *** REVIEWS *** TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976
HS Code 29222900
26094-21-3 structure

26094-21-3

~%

461-78-9 structure

461-78-9

Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; Location in patent: Page/Page column 77 ; US 20120252802 A1
5468-97-3 structure

5468-97-3

~%

461-78-9 structure

461-78-9

Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1
78558-98-2 structure

78558-98-2

~%

461-78-9 structure

461-78-9

Literature: Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342
104-83-6 structure

104-83-6

~%

461-78-9 structure

461-78-9

Literature: Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342
52449-43-1 structure

52449-43-1

~%

461-78-9 structure

461-78-9

Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1
HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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