Name | 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione |
---|---|
Synonyms |
1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,7-dihydro-1,8-dimethyl-
3-(2-Furylmethyl)-1,8-dimethyl-3,7-dihydro-1H-purine-2,6-dione furafylline 3-Furfuryl-1,8-dimethylxanthine 3-(furan-2-ylmethyl)-1,8-dimethyl-3,7-dihydro-1H-purine-2,6-dione |
Description | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM. |
---|---|
Related Catalog | |
Target |
IC50: 0.07 μM (human cytochrome P450IA2)[1] |
In Vivo | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA[1]. |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Boiling Point | 543.6±60.0 °C at 760 mmHg |
Molecular Formula | C12H12N4O3 |
Molecular Weight | 260.249 |
Flash Point | 282.6±32.9 °C |
Exact Mass | 260.090942 |
PSA | 85.82000 |
LogP | -0.24 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.637 |
Storage condition | 2-8℃ |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2939590000 |
HS Code | 2939590000 |
---|