1891-29-8

1891-29-8 structure

Name: Lactucin
Chemical Name: 4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-2,7-dione
CAS Number: 1891-29-8
Molecular Formula: C₁₅H₁₆O₅
Molecular Weight: 276.28500
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-04-12 22:40:16
Modify Date: 2024-01-03 17:53:52
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4].

Name	4-hydroxy-9-(hydroxymethyl)-6-methyl-3-methylidene-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-2,7-dione
Synonyms	Lactucin

Description	Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Research Areas >> Inflammation/Immunology
In Vitro	Lactucin shows moderate inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages[1]. Lactucin (0-100 µM, 24 and 48 h) induces cytotoxic effects in HL-60 cells in a dose– and time-dependent manner[3]. Lactucin (0-100 µM, 48 h) induces apoptosis and sub-G1 cell cycle arrest in HL-60 cells[3]. Lactucin (10 μg/mL, 48 h) completely prevents Plasmodium falciparum parasitemia[4]. Cell Viability Assay[3] Cell Line: HL-60 Concentration: 0, 5, 25, 50, and 100 µM Incubation Time: 24 and 48 h Result: Induced significant cytotoxic effects in these cancer cells in a dose– and time-dependent manner. Apoptosis Analysis[3] Cell Line: HL-60 Concentration: 0, 5, 50 and 100 µM Incubation Time: 48 h Result: Induced apoptosis. Swelling of the mitochondria and endoplasmic reticulum (ER) was detected in the cells. Cell Cycle Analysis[3] Cell Line: HL-60 Concentration: 0, 5, 50 and 100 µM Incubation Time: 48 h Result: Induced sub-G1 cell cycle arrest.
In Vivo	Lactucin (15 and 30 mg/kg; i.p.; once) decreases the spontaneous locomotor activity and shows analgesic properties in mice[2]. Animal Model: Male Albino-Swiss mice (18-24 g)[2] Dosage: 15 and 30 mg/kg Administration: Intraperitoneal injection, once Result: Decreased the spontaneous locomotor activity and showed analgesic properties in the hot plate test.
References	[1]. Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170. [2]. Gromek D, et al. Biologically active preparations from Lactuca virosa L. Phytotherapy Research, 1992, 6(5): 285-287. [3]. Zhang F H, et al. Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest. Bangladesh Journal of Pharmacology, 2016, 11(2): 478-484. [4]. Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95(2-3):455-7.

Molecular Formula	C₁₅H₁₆O₅
Molecular Weight	276.28500
Exact Mass	276.10000
PSA	83.83000
LogP	0.28290
Vapour Pressure	1.2E-15mmHg at 25°C

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