- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Boc-C14-COOH
- Price: ￥726.0/1g ￥256.0/250mg ￥5626.0/10g ￥2886.0/5g
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: Boc-C14-COOH
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: Boc-C14-COOH
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Nanjing Peptide Biotech Ltd
- China
- Product Name: tert-Butyl Hydrogen Hexadecanedioate
- Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
- Purity: 98.0%
- Stocking Period: 7 Day
- Contact: jom
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 16-(tert-Butoxy)-16-oxopalmitic acid, tert-Butyl 15-carboxypentadecanoate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
843666-27-3
843666-27-3 structure
- Name: Boc-C14-COOH
- Chemical Name: 16-[(2-methylpropan-2-yl)oxy]-16-oxohexadecanoate
- CAS Number: 843666-27-3
- Molecular Formula: C20H38O4
- Molecular Weight: 341.50500
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2017-02-05 06:39:59
- Modify Date: 2024-01-02 18:04:48
-
Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
| Name | 16-[(2-methylpropan-2-yl)oxy]-16-oxohexadecanoate |
|---|---|
| Synonyms |
mono-tert-butyl hexadecandioate
hexadecanedioic acid mono-tert-butyl ester tert-Butyl hydrogen hexadecanedioate |
| Description | Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 0.959±0.06 g/cm3 |
|---|---|
| Melting Point | 58.0-62.0°C |
| Molecular Formula | C20H38O4 |
| Molecular Weight | 341.50500 |
| Exact Mass | 341.26900 |
| PSA | 66.43000 |
| LogP | 4.53940 |
| Water Solubility | Insuluble (2.9E-3 g/L) (25 ºC) |
| HS Code | 2918990090 |
|---|
|
~33%
843666-27-3 |
| Literature: NOVO NORDISK A/S Patent: WO2007/128817 A2, 2007 ; Location in patent: Page/Page column 81 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |