134724-87-1

134724-87-1 structure

Name: 2-Phthalimidehydroxy-acetic acid
Chemical Name: 2-(1,3-dioxoisoindol-2-yl)oxyacetic acid
CAS Number: 134724-87-1
Molecular Formula: C₁₀H₇NO₅
Molecular Weight: 221.16600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-07-28 22:45:00
Modify Date: 2025-08-27 02:08:44
2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(1,3-dioxoisoindol-2-yl)oxyacetic acid
Synonyms	N-(Phth)-AOGly-OH phthalmidooxyacetic acid PhthN-O-Gly-OH 2-((1,3-dioxoisoindolin-2-yl)oxy)acetic acid phthalimidooxyacetic acid phthalimido-aminooxyacetic acid Pht-Aoaa-OH Acetic acid,[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]

Description	2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

54224-25-8

~99%

134724-87-1

Literature: Organic and Biomolecular Chemistry, , vol. 6, # 17 p. 3065 - 3078

524-38-9

79-08-3

~70%

134724-87-1

Literature: Journal of the American Chemical Society, , vol. 133, # 19 p. 7469 - 7475

524-38-9

134724-87-1

Literature: US2012/322978 A1, ;

Precursor 3
54224-25-8 524-38-9 79-08-3
DownStream 0