105114-63-4

105114-63-4 structure

Name: ZK112993
Chemical Name: (8S,11R,13S,14S,17S)-11-(4-acetylphenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number: 105114-63-4
Molecular Formula: C₂₉H₃₂O₃
Molecular Weight: 428.56300
Catalog: Research Areas Cancer
Create Date: 2017-11-10 23:28:23
Modify Date: 2024-04-02 21:32:32
ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].

Name	(8S,11R,13S,14S,17S)-11-(4-acetylphenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Synonyms	Estra-4,9-dien-3-one,11-(4-acetylphenyl)-17-hydroxy-17-(1-propynyl)-,(11beta,17beta) ZK 112,993

Description	ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice[1].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Cancer
References	[1]. C A Sartorius, et al. Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem. 1993 May 5;268(13):9262-6. [2]. Claudia Lanari, et al. Antiprogestins in breast cancer treatment: are we ready? Endocr Relat Cancer. 2012 May 3;19(3):R35-50.