473-41-6

473-41-6 structure

Name: Tolbutamide Sodium
Chemical Name: sodium,butylcarbamoyl-(4-methylphenyl)sulfonylazanide
CAS Number: 473-41-6
Molecular Formula: C₁₂H₁₈N₂O₃S
Molecular Weight: 270.34800
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-01-07 23:11:53
Modify Date: 2025-09-11 11:45:08
Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2].

Name	sodium,butylcarbamoyl-(4-methylphenyl)sulfonylazanide
Synonyms	Orinase Diagnostic Sodium tolbutamide Sodium butamide Urea,1-butyl-3-(p-tolylsulfonyl)-,sodium salt TOLBUTAMIDE SODIUM Sodium orinase 1-Butyl-3-(p-tolylsulfonyl)urea monosodium salt Tolbutamide sodium salt Tolbutamide sodium,sterile p-Toluenosulfonylbutylomocznik,sol sodowa [Polish]

Description	Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Metabolic Disease
References	[1]. Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407(5):493-9. [2]. Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273(50):33501-7.