137319-34-7

137319-34-7 structure

Name: Dehydroeffusol
Chemical Name: Dehydro Effusol
CAS Number: 137319-34-7
Molecular Formula: C₁₇H₁₄O₂
Molecular Weight: 250.29200
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-10-16 23:06:44
Modify Date: 2024-01-06 19:49:19
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].

Name	Dehydro Effusol
Synonyms	5-ethenyl-1-methylphenanthrene-2,7-diol 5-Ethenyl-1-methyl-2,7-phenanthrenediol Dehydroeffusol

Description	Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2]. Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].
References	[1]. Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18. [2]. Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.