129683-93-8
129683-93-8 structure
- Name: artonin E
- Chemical Name: 5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one
- CAS Number: 129683-93-8
- Molecular Formula: C25H24O7
- Molecular Weight: 436.45400
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2016-03-02 10:55:50
- Modify Date: 2024-01-02 18:34:43
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Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research[1].
| Name | 5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)-2-(2,4,5-trihydroxyphenyl)pyrano[2,3-h]chromen-4-one |
|---|---|
| Synonyms |
Artonin E
5'-Hydroxymorusin |
| Description | Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Artonin E (0-100 μg/mL, 24-72 h) 作用于 SKOV-3 细胞、T1074 细胞、人牙周膜成纤维细胞和 CHO 细胞的 IC50 值分别是 12.83、44.8、67 和 57.6 μg/mL。并且可以以时间依赖性方式降低 SKOV-3 细胞的细胞活力[1]。 Artonin E (0-20 μg/mL, 24 h) 可以以剂量依赖性方式抑制 SKOV-3 细胞集落形成，在 5 μg/mL 下，几乎一半的菌落减少，在用 15 和 20 μg/mL时，没有形成集落[1]。 Artonin E (8 μg/mL, 24-72 h) 可以诱导处于 S 期的 SKOV-3 细胞耗竭，72 小时时，S 期停滞的细胞积累显着增加，同时 G0/G1 期细胞比例下降[1]。 Cell Cycle Analysis[1] Cell Line: SKOV-3 cell lines Concentration: 8 μg/mL Incubation Time: 24, 48, 72 h Result: Induced ROS formation. Induced disruption of mitochondrial membrane potential and release of cytochrome c. Significantly upregulated the protein expression levels of caspase-9 and -3,up-regulated Bax and inhibited the expression of Bcl-2, HSP70 and survivin. |
| References |
| Density | 1.359g/cm3 |
|---|---|
| Boiling Point | 698.7ºC at 760 mmHg |
| Molecular Formula | C25H24O7 |
| Molecular Weight | 436.45400 |
| Flash Point | 241.5ºC |
| Exact Mass | 436.15200 |
| PSA | 120.36000 |
| LogP | 4.97530 |
| Vapour Pressure | 3.59E-20mmHg at 25°C |
| Index of Refraction | 1.653 |