123297-90-5
123297-90-5 structure
- Name: 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
- Chemical Name: 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
- CAS Number: 123297-90-5
- Molecular Formula: C14H10O5
- Molecular Weight: 258.22600
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2016-05-12 04:59:13
- Modify Date: 2025-09-25 08:14:39
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STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1].
| Name | 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione |
|---|---|
| Synonyms |
(-)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furane-4,9-dione
(+/-)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione 5-hydroxy-2-(1-hydroxyethyl)benzo[f][1]benzofuran-4,9-dione SERRATIFOLIOL |
| Description | STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549) [1] |
| In Vitro | STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3. STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases. STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1]. Western Blot Analysis[1] Cell Line: MCF7 cells; MDA-MB-231 cells Concentration: 1 or 10 μM; 0.5, 1, 2, 4 μM Incubation Time: 1 h; 2 h Result: Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM. Reduced the phosphorylation of STAT3 in does dependent manner. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, MCF7 and A549 cells Concentration: 0-30 μM Incubation Time: 72 h Result: Showed moderate to strong growth inhibitory activity among the three cancer cell lines. |
| References |
| Density | 1.506g/cm3 |
|---|---|
| Boiling Point | 465ºC at 760 mmHg |
| Molecular Formula | C14H10O5 |
| Molecular Weight | 258.22600 |
| Flash Point | 235ºC |
| Exact Mass | 258.05300 |
| PSA | 87.74000 |
| LogP | 1.81390 |
| Vapour Pressure | 1.91E-09mmHg at 25°C |
| Index of Refraction | 1.668 |