881835-86-5

881835-86-5 structure

Name: Succinylacetone
Chemical Name: 4,6-dioxoheptanoic acid
CAS Number: 881835-86-5
Molecular Formula: C₇H₁₀O₄
Molecular Weight: 163.11500
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-04-04 17:26:04
Modify Date: 2024-01-13 09:53:49
4,6-Dioxoheptanoic acid-13C5 is the 13C labeled 4,6-Dioxoheptanoic acid[1]. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis[2].

Name	4,6-dioxoheptanoic acid
Synonyms	Succinylacetone-13C5 4,6-Dioxoheptanoic-3,4,5,6,7-13C5 Acid 4,6-Dioxoheptanoic Acid-13C5

Description	4,6-Dioxoheptanoic acid-13C5 is the 13C labeled 4,6-Dioxoheptanoic acid[1]. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis[2].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.