Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Demecolcine, N-methyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

7336-44-9

7336-44-9 structure

Name: Demecolcine, N-methyl-
Chemical Name: (7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
CAS Number: 7336-44-9
Molecular Formula: C₂₂H₂₇NO₅
Molecular Weight: 385.45300
Create Date: 2017-05-14 12:31:11
Modify Date: 2024-01-09 19:16:50

Name	(7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Synonyms	N,N-dimethyldeacetylcolchicine N-Methyldemecolcine N-Deacetyl-N,N-dimethylcolchicine Demecolcine,N-methyl N,N-Dimethyl-desacetyl-colchicin N-Methyl-demecolcin Methylademecolcine,N N-methyldemocolcine COLCHICINE,N-DEACETYL-N,N-DIMETHYL N-Methylcolchamine

Density	1.2g/cm3
Boiling Point	619.7ºC at 760 mmHg
Molecular Formula	C₂₂H₂₇NO₅
Molecular Weight	385.45300
Flash Point	328.6ºC
Exact Mass	385.18900
PSA	57.23000
LogP	3.29710
Index of Refraction	1.581

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0792000

CHEMICAL NAME :: Colchicine, N-deacetyl-N,N-dimethyl-

CAS REGISTRY NUMBER :: 7336-44-9

LAST UPDATED :: 198706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-N-O5

MOLECULAR WEIGHT :: 385.50

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

477-30-5

74-88-4

7336-44-9

Literature: Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Santavy Collection of Czechoslovak Chemical Communications, 1951 , vol. 16/17, p. 676,683 Show Details Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

50-00-0

64-18-6

477-30-5

7336-44-9

Literature: Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Ueno Yakugaku Zasshi, 1953 , vol. 73, p. 1232,1233 Proceedings of the Japan Academy, 1953 , vol. 29, p. 266,269

50-00-0

64-18-6

3476-50-4

7336-44-9

Literature: Kiselew Doklady Akademii Nauk SSSR, 1954 , vol. 96, p. 527 Chem.Abstr., 1955 , p. 9005

Precursor 5
477-30-5 74-88-4 50-00-0 64-18-6
3476-50-4
DownStream 0

7336-44-9	25948-15-6
4421-04-9	90387-87-4
325715-02-4	90387-88-5
574739-36-9	89536-84-5
145679-21-6	102245-15-8