58337-35-2

58337-35-2 structure

Name: H9M2E
Chemical Name: 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol,acetate
CAS Number: 58337-35-2
Molecular Formula: C₂₀H₂₀N₂O₃
Molecular Weight: 336.38400
Catalog: Research Areas Cancer
Create Date: 2018-07-03 18:52:21
Modify Date: 2024-01-20 15:09:51
Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2].

Name	2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol,acetate
Synonyms	ELLIPTINIUM ACETATE Ellipticine acetomethylate 9-hydroxy-2-methylellipticinium acetate elliptinium Elliptinii acetas [INN-Latin] EINECS 261-216-0 Acetato de eliptinio [INN-Spanish] Acetate d'elliptinium [INN-French] Celiptium 9-hydroxy-N-2-methylellipticinium acetate Elliptinium acetate [INN:BAN] N2-Methylhydroxyellipticinium acetate N2-methyl-9-hydroxyellipticinium acetate

Description	Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer[1][2].
Related Catalog	Research Areas >> Cancer
Target	Nucleic acids[1][2].
In Vitro	Elliptinium (0.35 µM; 1 h) (9-OH-NME3) shows highly stable covalent bonding to nucleic acids of L1210 cells[1]. Cell Viability Assay[1] Cell Line: L1 210 cells Concentration: 0.35 µM Incubation Time: 1 h Result: Exhibited highly stable covalent bonding to DNA and RNA. Showed no reversal of binding as cells went on replicating during a 40-h period.

CHEMICAL NAME :: 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl-, acetate

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,281,1987

Precursor 0
DownStream 1
84303-55-9