133718-29-3
133718-29-3 structure
- Name: Revizinone
- Chemical Name: N-cyclohexyl-N-methyl-2-[(E)-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)-phenylmethylidene]amino]oxyacetamide
- CAS Number: 133718-29-3
- Molecular Formula: C26H29N5O3
- Molecular Weight: 459.54000
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2018-09-22 06:55:19
- Modify Date: 2024-01-13 23:03:51
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Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3]In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4]
| Name | N-cyclohexyl-N-methyl-2-[(E)-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)-phenylmethylidene]amino]oxyacetamide |
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| Synonyms |
UNII-6208ZO6MLG
Revizinone |
| Description | Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. target: phosphodiesterase (PDE)[3]; IC 50: 0.036 microM; [3]In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) was 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increased global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [4] |
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| Related Catalog | |
| References |
| Density | 1.336g/cm3 |
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| Boiling Point | 627.743ºC at 760 mmHg |
| Molecular Formula | C26H29N5O3 |
| Molecular Weight | 459.54000 |
| Flash Point | 333.447ºC |
| Exact Mass | 459.22700 |
| PSA | 86.60000 |
| LogP | 2.88190 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.677 |
| Storage condition | 2-8℃ |