CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
MV9000000
-
CHEMICAL NAME :
-
Hydrazine, phenyl-, hydrochloride
-
CAS REGISTRY NUMBER :
-
59-88-1
-
LAST UPDATED :
-
199710
-
DATA ITEMS CITED :
-
21
-
MOLECULAR FORMULA :
-
C6-H8-N2.Cl-H
-
MOLECULAR WEIGHT :
-
144.62
-
WISWESSER LINE NOTATION :
-
ZMR &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
161 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
2100 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
89 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
900 ug/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
25 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
500 mg/kg
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - cyanosis Skin and Appendages - corrosive (after topical exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
25 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
8000 mg/kg/42W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
464 mg/kg/8W-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
10 gm/kg/58W-C
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Blood - lymphoma, including Hodgkin's disease
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
928 mg/kg/8W-I
-
TOXIC EFFECTS :
-
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
30 mg/kg
-
SEX/DURATION :
-
female 17-19 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - behavioral
MUTATION DATA
-
TYPE OF TEST :
-
DNA repair
-
TEST SYSTEM :
-
Rodent - mouse Liver
-
REFERENCE :
-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,204,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81928 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1708 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81928 No. of Facilities: 63 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 645 (estimated) No. of Female Employees: 445 (estimated)
|