1196130-86-5

1196130-86-5 structure

Name: 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-6-yl)-1,2,4-oxadiazole,hydrochloride
Chemical Name: 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-6-yl)-1,2,4-oxadiazole,hydrochloride
CAS Number: 1196130-86-5
Molecular Formula: C₈H₁₃ClN₄O
Molecular Weight: 216.66800
Create Date: 2016-05-03 01:45:36
Modify Date: 2024-04-09 23:32:14
CDD0102 HCl is a selective and potent M1 muscarinic receptor agonist for the treatment of Alzheimer's disease.

Name	3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-6-yl)-1,2,4-oxadiazole,hydrochloride
Synonyms	MCD-386CR CDD-0102 hydrochloride UNII-6P87MRR8OA

Description	CDD0102 HCl is a selective and potent M1 muscarinic receptor agonist for the treatment of Alzheimer's disease.
In Vitro	In cell lines expressing M1 receptors, CDD0102 (CDD-0102) is an efficacious muscarinic agonist. CDD0102 exhibits much lower activity at M3 and M5 receptors[1].
In Vivo	Following i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. The LD50 of CDD0102 is 190 mg/kg in toxicological studies after i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration after oral administration at a dose of 10 mg/kg. No side effects are observed at this dose[1].
References	1. Messer WS Jr. The utility of muscarinic agonists in the treatment of Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):187-93.