39111-07-4
39111-07-4 structure
- Name: Nigranoic acid
- Chemical Name: nigranoic acid
- CAS Number: 39111-07-4
- Molecular Formula: C30H46O4
- Molecular Weight: 470.68400
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2016-06-04 17:11:15
- Modify Date: 2024-01-06 19:18:38
-
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].
| Name | nigranoic acid |
|---|
| Description | Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1 reverse transcriptase |
| In Vivo | Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2]. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2]. Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2] Dosage: 1 mg/kg Administration: Intragastric; 6 hours and 2 hours before brain ischemia Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
| References |
| Molecular Formula | C30H46O4 |
|---|---|
| Molecular Weight | 470.68400 |
| Exact Mass | 470.34000 |
| PSA | 74.60000 |
| LogP | 7.49360 |