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680611-86-3

680611-86-3 structure
680611-86-3 structure
  • Name: SGA360
  • Chemical Name: 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole
  • CAS Number: 680611-86-3
  • Molecular Formula: C19H17F3N2O2
  • Molecular Weight: 362.34600
  • Create Date: 2016-04-30 08:04:20
  • Modify Date: 2024-01-21 18:23:56
  • SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].

Name 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole
Synonyms SGA360
Description SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].
Related Catalog
In Vivo SGA360 exhibits anti-inflammatory activity in vivo.
References

[1]. Iain A Murray, et al. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17;23(5):955-66.

Molecular Formula C19H17F3N2O2
Molecular Weight 362.34600
Exact Mass 362.12400
PSA 36.28000
LogP 4.92530

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680611-86-3 structure

680611-86-3

Literature: WYETH Patent: WO2005/39582 A1, 2005 ; Location in patent: Page/Page column 36-38 ; WO 2005/039582 A1

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680611-86-3 structure

680611-86-3

Literature: Wyeth Patent: US2006/111574 A1, 2006 ; Location in patent: Page/Page column 5; 6 ;

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680611-86-3 structure

680611-86-3

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

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680611-86-3 structure

680611-86-3

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

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680611-86-3 structure

680611-86-3

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

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680611-86-3 structure

680611-86-3

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

~%

680611-86-3 structure

680611-86-3

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966