134377-69-8

134377-69-8 structure

Name: Safironil
Chemical Name: 2-N,4-N-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide
CAS Number: 134377-69-8
Molecular Formula: C₁₅H₂₃N₃O₄
Molecular Weight: 309.36100
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-04-05 08:00:00
Modify Date: 2024-04-08 05:18:43
Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].

Name	2-N,4-N-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide
Synonyms	n,n'-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide UNII-CK4M8AX1LN N,N'-di-(3-methoxypropyl)pyridine-2,4-dicarboxamide Safironil

Description	Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012) [2]. Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152(1):279-87.