484049-04-9
484049-04-9 structure
- Name: DPH
- Chemical Name: 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione
- CAS Number: 484049-04-9
- Molecular Formula: C18H13FN4O2
- Molecular Weight: 336.32000
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2019-01-01 15:28:32
- Modify Date: 2025-08-27 21:25:47
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DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.
| Name | 5-[3-(4-fluorophenyl)-1-phenylpyrazol-4-yl]imidazolidine-2,4-dione |
|---|---|
| Synonyms |
5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione
HMS2301N21 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione DPH |
| Description | DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation. |
|---|---|
| Related Catalog | |
| In Vitro | DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1]. |
| References |
| Molecular Formula | C18H13FN4O2 |
|---|---|
| Molecular Weight | 336.32000 |
| Exact Mass | 336.10200 |
| PSA | 83.00000 |
| LogP | 2.47480 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
|---|