Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4H-Dibenzo[de,g]quinolin-9-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (6aS)-
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128-76-7

128-76-7 structure

Name: 4H-Dibenzo[de,g]quinolin-9-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (6aS)-
Chemical Name: 1,2,10-trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol
CAS Number: 128-76-7
Molecular Formula: C₁₉H₂₁NO₄
Molecular Weight: 327.37400
Catalog: Research Areas Cancer
Create Date: 2018-08-30 18:54:19
Modify Date: 2025-08-27 16:07:12
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways[1].

Name	1,2,10-trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol

Description	Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways[1].
Related Catalog	Research Areas >> Cancer
In Vivo	Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; 每天，持续 21 天; SD 大鼠) 通过下调 MUC5AC 和 NF-κB 信号通路发挥抗哮喘作用。 Animal Model: Sprague Dawley (SD) rats (180-220g) [1] Dosage: 20, 40, and 60 mg/kg Administration: Oral administration; daily, for 21 days Result: Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages. Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ. Reduced serum IgE and histamine. Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
References	[1]. Xin XX, et, al. Anti-asthmatic effect of laurotetanine extracted from Litsea cubeba (Lour.) Pers. root on ovalbumin-induced allergic asthma rats, and elucidation of its mechanism of action. TROP J PHARM RES. 2019:18(6).

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980