95522-45-5
95522-45-5 structure
- Name: 2-(chloromethyl)oxirane,2-methyl-1H-imidazole
- Chemical Name: 2-(chloromethyl)oxirane,2-methyl-1H-imidazole
- CAS Number: 95522-45-5
- Molecular Formula: C7H11ClN2O
- Molecular Weight: 174.62800
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-06-16 00:36:38
- Modify Date: 2024-01-09 20:25:18
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Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research[1][2].
| Name | 2-(chloromethyl)oxirane,2-methyl-1H-imidazole |
|---|---|
| Synonyms |
Colestilan
Epichlorohydrin-2-methylimidazole copolymer Colestimide MCI 196 Cholebine |
| Description | Colestilan (MCI-196) is a non-absorbed, non-calcium-based phosphate binder and is also a non-metallic, anion exchange resin. Colestilan is orally active and can be used for hypercholesterolaemia research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Colestilan (MCI-196) decreases cholesterol levels by bile acid adsorption through the gastrointestinal tract[2]. Colestilan (1 g) binds 2.52 mmol of phosphate at 2–4 mM phosphate concentration and pH7.2 in vitro[2]. |
| In Vivo | Colestilan (MCI-196) (0.125 or 0.5 g content per 15 g of the feed; p.o.; 14 days) decreases blood phosphate and urinary phosphorus excretion in rats[3]. Colestilan is able to improve hyperphosphataemia in rats with renal failure induced by adenine administration for 4 weeks[1]. Animal Model: 6-week old Wistar male rats[3] Dosage: 0.125 or 0.5 g content per 15 g of the feed Administration: Oral in feed, 14 days Result: Dose dependently decreased blood phosphate and urinary phosphate excretion. |
| References |
| Molecular Formula | C7H11ClN2O |
|---|---|
| Molecular Weight | 174.62800 |
| Exact Mass | 174.05600 |
| PSA | 41.21000 |
| LogP | 1.34210 |