131875-08-6

131875-08-6 structure

Name: Lexacalcitol
Chemical Name: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
CAS Number: 131875-08-6
Molecular Formula: C₂₉H₄₈O₄
Molecular Weight: 460.689
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2018-02-22 08:00:00
Modify Date: 2024-01-12 11:52:40
Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

Name	(1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-(4-ethyl-4-hydroxyhexoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Synonyms	(5Z,7E,20R)-20-((4-Ethyl-4-hydroxyhexyl)oxy)-9,10-secopregna-5,7,10(19)-triene-1a,3b-diol LEVORPHANOL TARTRATE DIHYDRATE (1S-(1a(S),3ab,4E(1S,3R*,5Z),7aa))-5-((1-(1-((4-Ethyl-4-hydroxyhexyl)oxy)ethyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol LEVORPHANOL TARTRATE L-3-HYDROXY-N-METHYLMORPHINAN Lexacalcitol LEVORPHANOL TARTRATE SALT Levo-dromoran (tn) Levorphanol Tartrate CII (500 mg) Levorphanol Tartrate (CII),USP 1,3-Cyclohexanediol, 5-[(2E)-2-[(1S,3aS,7aS)-1-[(1R)-1-[(4-ethyl-4-hydroxyhexyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (1S,3R,5Z,7E,9ξ,20R)-20-[(4-Ethyl-4-hydroxyhexyl)oxy]-9,10-secopregna-5,7,10-triene-1,3-diol 20-epi-22-oxa-24a,26a,27a-tri-homo-1,25-dihydoxyvitamin D3 (1S,3R,5Z,7E,9ξ,20R)-20-[(4-Ethyl-4-hydroxyhexyl)oxy]-9,10-secopregna-5,7,10-trien-1,3-diol UNII:9G3DCA3958 levorphanol tartrate methanol solution LEVORPHANOLTARTRATE,USP

Description	Lexacalcitol (KH1060), a vitamin D analog, is potent regulators of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Inflammation/Immunology
In Vitro	Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1]. Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].
In Vivo	Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2]. Animal Model: Male and female spontaneously diabetic NOD mice[2] Dosage: 0.5 mg/kg/2 days Administration: Intraperitoneal injection Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
References	[1]. L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75. [2]. C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365.

Density	1.1±0.1 g/cm3
Boiling Point	600.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₉H₄₈O₄
Molecular Weight	460.689
Flash Point	316.8±31.5 °C
Exact Mass	460.355255
PSA	69.92000
LogP	5.62
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.542
Storage condition	2-8℃