DC Chemicals Limited
China
Product Name: N-(p-Amylcinnamoyl) anthranilic Acid (ACA)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

110683-10-8

110683-10-8 structure

Name: N-(p-amylcinnamoyl) Anthranilic Acid
Chemical Name: aca
CAS Number: 110683-10-8
Molecular Formula: C₂₁H₂₃NO₃
Molecular Weight: 337.41
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-09-13 23:44:09
Modify Date: 2024-01-19 14:49:35
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].

Name	aca
Synonyms	2-{[(2E)-3-(4-Pentylphenyl)-2-propenoyl]amino}benzoic acid 4-amylcinnamoylanthranilicacid 2-{[(2E)-3-(4-pentylphenyl)prop-2-enoyl]amino}benzoic acid Benzoic acid, 2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-

Description	N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Target	PLA2[1][2]. TRP channel[1][2].Calcium-activated chloride channels[3].
In Vitro	N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells[1]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition[1].
References	[1]. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. [2]. Harteneck C, et al. N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25(1):61-75. [3]. Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N-(p-amylcinnamoyl)anthranilic acid (ACA). Biochem Biophys Res Commun. 2010 Nov 19;402(3):531-6.

Density	1.2±0.1 g/cm3
Boiling Point	563.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₃NO₃
Molecular Weight	337.41
Flash Point	294.4±30.1 °C
Exact Mass	337.167786
PSA	66.40000
LogP	7.11
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.629
Storage condition	-20℃

HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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