32886-15-0
32886-15-0 structure
- Name: Lipoxamycin
- Chemical Name: Lipoxamycin
- CAS Number: 32886-15-0
- Molecular Formula: C19H36N2O5
- Molecular Weight: 372.50000
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2017-10-25 16:37:37
- Modify Date: 2024-03-02 16:08:48
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Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
| Name | Lipoxamycin |
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| Synonyms | lipoxamycin |
| Description | Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2]. |
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| Related Catalog | |
| Target |
Serine palmitoyltransferase[1] |
| In Vitro | Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1]. Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1]. |
| In Vivo | Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1]. |
| References |
| Molecular Formula | C19H36N2O5 |
|---|---|
| Molecular Weight | 372.50000 |
| Exact Mass | 372.26200 |
| PSA | 120.93000 |
| LogP | 2.91930 |
| HS Code | 2924199090 |
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| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |