439239-92-6
439239-92-6 structure
- Name: Lasmiditan hemisuccinate
- Chemical Name: butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide
- CAS Number: 439239-92-6
- Molecular Formula: C42H42F6N6O8
- Molecular Weight: 872.80900
- Create Date: 2018-06-13 14:41:51
- Modify Date: 2024-01-14 10:18:21
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Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
| Name | butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide |
|---|---|
| Synonyms |
Lasmiditan succinate (USAN)
2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate UNII-W64YBJ346B Lasmiditan succinate Lasmiditan hemisuccinate |
| Molecular Formula | C42H42F6N6O8 |
|---|---|
| Molecular Weight | 872.80900 |
| Exact Mass | 872.29700 |
| PSA | 206.18000 |
| LogP | 7.13100 |