243975-37-3

243975-37-3 structure

Name: Argifin
Chemical Name: (2R,5S,8S,11S,15S)-5-[3-[[amino-(methylcarbamoylamino)methylidene]amino]propyl]-8-benzyl-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentazacycloheptadecane-11,15-dicarboxylic acid
CAS Number: 243975-37-3
Molecular Formula: C₂₉H₄₁N₉O₁₀
Molecular Weight: 675.69000
Catalog: Research Areas Infection
Create Date: 2017-11-16 08:18:21
Modify Date: 2024-01-05 09:18:30
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

Name	(2R,5S,8S,11S,15S)-5-[3-[[amino-(methylcarbamoylamino)methylidene]amino]propyl]-8-benzyl-2,7-dimethyl-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentazacycloheptadecane-11,15-dicarboxylic acid
Synonyms	FTD 0668 1wb0 1w9v Argifin

Description	Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 0.025 μM (SmChiA), 6.4 μM (SmChiB), 1.1 μM (Aspergillus fumigatus chitinase B1), 4.5 μM (human chitotriosidase)[1]
In Vitro	Argifin inhibits L. cuprina chitinase with IC50 values of 3.7 μM at 37 ºC and 0.10 μM at 20 ºC[1].
In Vivo	Argifin has the ability to inhibit L. cuprina molting[1].
References	[1]. Hirose T, et al. Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):85-102.