321351-00-2
321351-00-2 structure
- Name: EO 1428
- Chemical Name: [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone
- CAS Number: 321351-00-2
- Molecular Formula: C20H16BrClN2O
- Molecular Weight: 415.71100
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2016-12-23 00:57:17
- Modify Date: 2025-08-26 09:54:56
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EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1].
| Name | [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone |
|---|---|
| Synonyms |
eo 1428
hms3266h20 unii-mv2rhj680o hms3229j13 |
| Description | EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.483g/cm3 |
|---|---|
| Boiling Point | 515.935ºC at 760 mmHg |
| Molecular Formula | C20H16BrClN2O |
| Molecular Weight | 415.71100 |
| Flash Point | 265.828ºC |
| Exact Mass | 414.01300 |
| PSA | 55.12000 |
| LogP | 6.62190 |
| Index of Refraction | 1.689 |
| HS Code | 2922399090 |
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~99%
321351-00-2 |
| Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662 |
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~%
321351-00-2 |
| Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662 |
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~%
321351-00-2 |
| Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662 |
|
~%
321351-00-2 |
| Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662 |
|
~%
321351-00-2 |
| Literature: Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| HS Code | 2922399090 |
|---|---|
| Summary | 2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |