- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: danshenol A
- Price: Check
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Danshenol A
- Price: ￥3900.0/5mg
- Purity: 97.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: danshenol A
- Price: ￥4908.0/5mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: danshenol A
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
189308-08-5
189308-08-5 structure
- Name: danshenol A
- Chemical Name: (1R,10S)-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)-1,2-dihydronaphtho[1,2-g][1]benzofuran-11-one
- CAS Number: 189308-08-5
- Molecular Formula: C21H20O4
- Molecular Weight: 336.38100
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldose Reductase
- Create Date: 2016-01-11 08:15:17
- Modify Date: 2025-08-23 22:38:47
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Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].
| Name | (1R,10S)-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)-1,2-dihydronaphtho[1,2-g][1]benzofuran-11-one |
|---|---|
| Synonyms | Danshenol A |
| Description | Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.1 μM (Aldose reductase)[3] |
| In Vitro | Danshenol A (10 nM; pretreatment for 1 h) 单独处理显示对 ICAM-1 在 mRNA 和蛋白质水平的表达没有影响。Danshenol A 显着逆转 TNF-α 诱导的 ICAM-1 表达和随后的单核细胞粘附，以及升高的活性氧 (ROS) 生成和 NOX4 表达[1]. Danshenol A 通过 NOX4 依赖性 IKKβ/NF-κB 通路抑制 TNF-α 诱导的 ICAM-1 表达和随后的单核细胞与内皮细胞的粘附[1]。 Danshenol A (1, 3, and 10 μM; pretreated for 35 min) 恢复血管紧张素 II 诱导的心肌细胞凋亡。此外，Danshenol A 抑制心肌细胞线粒体氧化还原信号通路[2]。 Danshenol A 抑制 K562 (IC50 = 0.53 μg/mL)、T-24 (IC50 = 7.94 μg/mL)、QGY (IC50 = 4.65 μg/mL) 和 Me180 (IC50 = 6.89 μg/mL) 细胞系的活性[4]。 Western Blot Analysis[1] Cell Line: HUVEC cells Concentration: 10 nM Incubation Time: Pretreatment for 1 h Result: Showed no effect on the ICAM-1 expression at both mRNA and protein levels. |
| In Vivo | Danshenol A (0.3-3mg/kg；口服；每天一次；持续 12 周) 改善 SHR 大鼠的血压、心脏损伤和心肌胶原体积，并改善心功能。Danshenol A 修复线粒体结构/功能，减轻心肌氧化应激[2]。 Animal Model: Forty male spontaneously hypertensive rats (SHR) and eight male Wistar-Kyoto (WKY) rats at the age of 16 weeks[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration: Orally administration; daily; for 12 weeks Result: Ameliorated blood pressure, cardiac injury, and myocardial collagen volume and improved cardiac function. |
| References |
| Density | 1.31±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.5ºC at 760 mmHg |
| Molecular Formula | C21H20O4 |
| Molecular Weight | 336.38100 |
| Flash Point | 206.6ºC |
| Exact Mass | 336.13600 |
| PSA | 63.60000 |
| LogP | 3.27500 |
| Vapour Pressure | 6.74E-14mmHg at 25°C |
| Index of Refraction | 1.653 |