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175033-36-0

175033-36-0 structure
175033-36-0 structure
  • Name: NCX-4016
  • Chemical Name: [3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
  • CAS Number: 175033-36-0
  • Molecular Formula: C16H13NO7
  • Molecular Weight: 331.27700
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2016-02-02 20:57:39
  • Modify Date: 2025-08-25 14:47:49
  • Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].
Name [3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate
Synonyms 3-nitrooxyphenyl acetylsalicylate
nitroaspirin
NO-ASA
Ncx 4016
m-NO-ASA
m-NO-aspirin
Description Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].
Related Catalog
Target

COX-1

References

[1]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.

[2]. Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43.

[3]. Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7.

[4]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.
Density 1.347g/cm3
Boiling Point 499.3ºC at 760mmHg
Melting Point 61-62ºC
Molecular Formula C16H13NO7
Molecular Weight 331.27700
Flash Point 214.3ºC
Exact Mass 331.06900
PSA 107.65000
LogP 3.06260
Vapour Pressure 4.21E-10mmHg at 25°C
Index of Refraction 1.58
Storage condition -20°C
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