132640-22-3

132640-22-3 structure

Name: Andolast
Chemical Name: 4-(2H-Tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]benzamide
CAS Number: 132640-22-3
Molecular Formula: C₁₅H₁₁N₉O
Molecular Weight: 333.30800
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2018-12-25 16:31:34
Modify Date: 2025-08-25 06:07:17
Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM.

Name	4-(2H-Tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl]benzamide
Synonyms	Benzamide,4-(2H-tetrazol-5-yl)-N-[4-(2H-tetrazol-5-yl)phenyl] N-4-(5-tetrazolyl)-phenyl-4-(5-tetrazolyl)-benzamide Andolast N-4-(5-tetrazolyl)-phenyl-4-(5-tatrazolyl)-benzamide N-4-(5-tetrazoyl)-phenyl-4-(5-tetrazolyl)-benzamide

Description	Andolast is an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast inhibits dose dependently guinea-pig lung cAMP-phosphodiesterase with an IC50 of 50 mM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Revel L, Colombo S, Ferrari F, Folco G, Rovati LC, Makovec F. CR 2039, a new bis-(1H-tetrazol-5-yl)phenylbenzamide derivative with potential for the topical treatment of asthma. Eur J Pharmacol. 1992;229(1):45-53. [2]. Czuczwar SJ, Gasior M, Kozicka M, Pietrasiewicz T, Turski WA, Kleinrok Z. A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice. Eur Neuropsychopharmacol. 1998;8(3):233-238.