CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
UY9450000
-
CHEMICAL NAME :
-
7H-Pyrrolo(2,3-d)pyrimidin-4-ol, 7-beta-D-ribofuranosyl-
-
CAS REGISTRY NUMBER :
-
2862-16-0
-
LAST UPDATED :
-
199612
-
DATA ITEMS CITED :
-
6
-
MOLECULAR FORMULA :
-
C11-H13-N3-O5
-
MOLECULAR WEIGHT :
-
267.27
-
WISWESSER LINE NOTATION :
-
T56 BN GN INJ FQ I- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
26 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - peritonitis Liver - hepatitis (hepatocellular necrosis), zonal Lungs, Thorax, or Respiration - acute pulmonary edema
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
25 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - peritonitis Liver - hepatitis (hepatocellular necrosis), zonal Lungs, Thorax, or Respiration - acute pulmonary edema
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
24 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - peritonitis Liver - hepatitis (hepatocellular necrosis), zonal Lungs, Thorax, or Respiration - acute pulmonary edema
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
30 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - peritonitis Liver - hepatitis (hepatocellular necrosis), zonal Lungs, Thorax, or Respiration - acute pulmonary edema
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
48 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
48 mg/kg
-
TOXIC EFFECTS :
-
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
REFERENCE :
-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,116,1969
|
