Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Purine-2,6-dione,3,9-dihydro-1,3-dimethyl-8-[[(phenylmethyl)thio]methyl]-
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6466-43-9

6466-43-9 structure

Name: TPBM
Chemical Name: 8-(benzylsulfanylmethyl)-1,3-dimethyl-7H-purine-2,6-dione
CAS Number: 6466-43-9
Molecular Formula: C₁₅H₁₆N₄O₂S
Molecular Weight: 316.37800
Catalog: Research Areas Cancer
Create Date: 2016-03-05 23:19:02
Modify Date: 2024-01-03 12:57:08
TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].

Name	8-(benzylsulfanylmethyl)-1,3-dimethyl-7H-purine-2,6-dione
Synonyms	tpbm

Description	TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	IC50: 9 μM (17β-estradiol (E2)-ERα)[1]
References	[1]. Mao C, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283(19):12819-12830.

RIDADR	NONH for all modes of transport